LRIG1 expression and colorectal cancer prognosis

Abstract Background To make the right treatment decisions about colorectal cancer (CRC) patients reliable predictive and prognostic data are needed. However, in many cases this is not enough. Some studies suggest that LRIG1 gene ( leucine-rich repeats immunoglobulin-like domains1 ) has implications different kinds of cancers. Methods One hundred two with were retrospectively analyzed for expression at both mRNA protein levels. SYBR Green Real-Time RT-PCR technique was used analyses Glyceraldehyde-3-Phosphate Dehydrogenase GAPDH considered as a reference normalization. using Immunohistochemistry. Additionally, appropriate statistic to assess test control groups. The significance univariate multivariate analyses. Results revealed levels down regulated tumor tissues P < 0.01) but clinically relevant indicator CRC. Conclusions Therefore, it suggested may be an important issue when making informed individualized clinical regarding management patients.